This review discusses treatment strategies for wrinkles and skin defects through an in-depth overview of current soft tissue fillers utilized within the fields of dermatology and plastic surgery. From the review, it is evident that the utilization of different materials for various skin abnormalities is extremely wide in scope. Many clinicians have adopted their own preferences based on not only the knowledge provided by their experience but also the respective profiles of each individual filler, including their efficacy, practicality and safety. With the ongoing emergence of commercially available products designed for soft tissue augmentation, the market will continue to present new and improved treatment options. Although the search for the perfect or most ideal filler is far from over, this review demonstrates that there are a number of commercially available products that are more than acceptable to both patients and clinicians in the treatment of wrinkles and other skin defects.